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| The Black Death (Bubonic Plague) - 200 million < deaths |
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| The Great Influenza, 1918 Spanish Flu Pandemic - 100 million < deaths |
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| Plague of Justinian - 50 million deaths |
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| Malaria - 750,000 < deaths |
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| Smallpox - 90 million < deaths |
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| Tuberculosis - 1 billion < deaths |
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| Epidemic Typhus Camp Fever - 10 million deaths |
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| HIV AIDS - 30 million < deaths |
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| Antonine Plague - 5 million deaths |
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| Cholera - 200,000 < deaths |
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